Sildenafil (Viagra) Induces Neurogenesis and Promotes Functional Recovery After Stroke
نویسندگان
چکیده
Ruilan Zhang, Ying Wang, Li Zhang, Zhenggang Zhang, Wayne Tsang, Mei Lu, Lijie Zhang in Rats Sildenafil (Viagra) Induces Neurogenesis and Promotes Functional Recovery After Stroke Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.0000034399.95249.59 2002;33:2675-2680 Stroke. http://stroke.ahajournals.org/content/33/11/2675 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats.
BACKGROUND AND PURPOSE We tested the hypothesis that sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, promotes functional recovery and neurogenesis after stroke. METHODS Male Wistar rats were subjected to embolic middle cerebral artery occlusion. Sildenafil (Viagra) was administered orally for 7 consecutive days starting 2 or 24 hours after stroke onset at doses of 2 or 5 mg/kg per da...
متن کاملFunctional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor.
BACKGROUND AND PURPOSE Advanced age is associated with a decrease in brain plasticity compared with the young adult. Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor promotes brain plasticity and improves functional outcome after stroke in the young animal. Here, we test the hypothesis that sildenafil provides restorative therapeutic benefit to the aged animal. METHODS Male Wistar rats...
متن کاملCerebral haemodynamic response or excitability is not affected by sildenafil.
Sildenafil (Viagra), a cyclic guanosine monophosphate-degrading phosphodiesterase 5 inhibitor, induces headache and migraine. Such headache induction may be caused by an increased neuronal excitability, as no concurrent effect on cerebral arteries is found. In 13 healthy females (23+/-3 years, 70.3+/-6.6 kg), the effect of sildenafil on a visual (reversing checkerboard) and a hypercapnic (6% CO...
متن کاملA neurovascular niche for neurogenesis after stroke.
Stroke causes cell death but also birth and migration of new neurons within sites of ischemic damage. The cellular environment that induces neuronal regeneration and migration after stroke has not been defined. We have used a model of long-distance migration of newly born neurons from the subventricular zone to cortex after stroke to define the cellular cues that induce neuronal regeneration af...
متن کاملSildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits.
Sildenafil citrate (Viagra) is the pharmacological agent used to treat erectile dysfunction in men. Because this drug has a vasodilatory effect, we hypothesized that such an action may induce a preconditioning-like cardioprotective effect via opening of mitochondrial ATP-sensitive K (K(ATP)) channels. Rabbits were treated with sildenafil citrate (0.7 mg/kg iv) either 30 min (acute phase) or 24 ...
متن کامل